We investigate the large-scale distribution of the HII regions in a sample of 6 nearby spiral galaxies for which we have obtained deep Ha images. By performing azimuthally averaged radial profiles we find that for all the galaxies the radial distribution of the HII regions is well approximated by an exponential law. We also examine the HII region size distribution and we derive that the average size is ~100 pc while the largest ones may be as much as ~1 kpc.